Identification of G α 12 and G α 13 Determinants of Binding to Cell Adhesion Proteins

G 12 / G 13 Family G Proteins Regulate Marginal Zone B Cell

Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11).

Integrin-mediated adhesion is a crucial step in lymphocyte extravasation and homing. We show here that not only the chemokines CXCL12 and CXCL13 but also the lysophospholipids sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA) enhance adhesion of murine follicular and marginal zone B cells to ICAM-1 in vitro. This process involves clustering of integrin LFA-1 and is blocked by pertus...

functional study of p0 proteins of two cereal yellow dwarf viruses (cydv-rpv and cydv-rps) and identification of their cellular partner

نقش سرکوبگری پروتئین p0 در دو پولروویروس کوتولگی زردی غلات cydv-rpv) و (cydv-rps، متفاوت در شدت بیماریزایی، مورد مطالعه قرار گرفت. نتایج نشان داد که هر دو پروتئین p0 p0cy-rpv) و (p0cy-rps قادر به سرکوب خاموشی آر ان ای ایجاد شده توسط ترادف های تراژن سنس و تکرار معکوس در n. benthamiana هستند. نشان داده شد که هر دو پروتئین p0 می توانند تخریب پروتئین argonaute-1 را تسهیل کنند. علاوه بر این، تمایل م...

Interaction of G 12 with G 13 and G q signaling pathways

The G12 subfamily of heterotrimeric G-proteins consists of two members, G12 and G13. Gene-targeting studies have revealed a role for G13 in blood vessel development. Mice lacking the subunit of G13 die around embryonic day 10 as the result of an angiogenic defect. On the other hand, the physiological role of G12 is still unclear. To address this issue, we generated G 12-deficient mice. In contr...

On the functions with values in [α(G), χ(G)]

Let B(G) = {X : X ∈ Rn×n,X = X , I ≤ X ≤ I + A(G)} and C(G) = {X : X ∈ Rn×n,X = X , I − A(G) ≤ X ≤ I + A(G)} be classes of matrices associated with graph G. Here n is the number of vertices in graph G, and A(G) is the adjacency matrix of this graph. Denote r(G) = minX∈C(G) rank(X), r+(G) = minX∈B(G) rank(X). We have shown previously that for every graph G, α(G) ≤ r+(G) ≤ χ(G) holds and α(G) = r...